Microcirculation-guided resuscitation in sepsis: the next frontier?

The Coronary Microcirculation in STEMI: The Next Frontier?

There have been significant reductions in the mortality associated with ST elevation myocardial infarction (STEMI) over the last several decades. On the background of declining coronary heart disease mortality in the USA and Western Europe, the use of prompt reperfusion strategies and adjunctive pharmacotherapy, mortality in STEMI patients has continued to improve. The 30-day mortality from fou...

Effects of volume resuscitation on the microcirculation in animal models of lipopolysaccharide sepsis: a systematic review

BACKGROUND Recent research has identified an increased rate of mortality associated with fluid bolus therapy for severe sepsis and septic shock, but the mechanisms are still not well understood. Fluid resuscitation therapy administered for sepsis and septic shock targets restoration of the macro-circulation, but the pathogenesis of sepsis is complex and includes microcirculatory dysfunction. ...

Reliability: the next frontier

The goal of my graduate research has been finding architectural solutions to key technological challenges facing processor design that impact reliability, power, and performance of multicores. The rapidly shrinking feature sizes provided by the Moore’s Law with each successive technology generation make the devices on a chip increasingly susceptible to soft errors, hard errors, process variatio...

The Next Frontier

Next Frontier